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JOIO (2026)

In intestinal Caco-2 cells, IL-1 decreases TER and increases inulin flux, which is in part mediated by the decreased expression and redistribution of occludin and increased expression of MLCK and MLC phosphorylation.46 It was also shown that the knockdown of nuclear factor-B p65 inhibits the decrease in occludin and increases in MLCK expression, indicating nuclear factor-B-dependent transcriptional regulation by IL-1.47 4

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P.NordbergM

Indian J Exp Biol 34(12):12081211 Hisamoto M, Kikuzaki H, Nakatani N (2004) Constituents of the leaves of Peucedanum japonicum Thunb

They may increase the solubility of the active substance, alter the absorption pathways, protect them from enzymatic degradation in the gastrointestinal (GI) tract, inhibit the ATP-binding cassette sub-family B member 1 (ABCB1) efflux transporter and the cytochrome P450 enzyme system and can be targeted to specific regions of the GI tract [135]