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Nevertheless, another study performed in the APP23xPS45 mice suggest that in the hippocampus hyperxcitability starts early and decreases with age, while hypoactivity increases over time, as shown in clinical studies [89,90]

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Wallert M, Ziegler M, Wang X, Maluenda A, Xu X, Yap ML, Witt R, Giles C, Kluge S, Hortmann M, Zhang J, Meikle P, Lorkowski S, Peter K (2019) -Tocopherol preserves cardiac function by reducing oxidative stress and inflammation in ischemia/reperfusion injury