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Protonation of the oxidant accelerates the reaction because the protonated form is a better electrophile, which is an opposite effect to the aforementioned favorable deprotonation of the thiol

In another asthma model related to oxidative stress, namely toluene-diisocyanate-induced (TDI), mice and rats exposed to oxidized graphene, single-walled carbon nanotubes, nano aluminum oxide, or other highly pro-oxidative substances, vitamin E administration decreased ROS [382,383,394,395]

Further, a placebo-controlled trial in 152 elderly adults (aged 70-80 years) with mild cognitive impairment reported that B vitamin supplementation (50 mg/day of vitamin B 6 , 5 mg/day of folic acid, and 0.4 mg/day of vitamin B 12 ) for one year did not improve performance on a similar test of verbal fluency (136)

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