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This blocks cell membrane biosynthesis and disrupts lipid second messenger balance, leading to cell cycle arrest in the S phase [154]

Firstly, the proposed mechanisms underlying DTP generation and survival, such as epigenetic plasticity, metabolic reprogramming, and immune evasion, are largely derived from pre-clinical models, with limited clinical validation in human cohorts

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Targeting Epidermal Growth Factor Receptor in triple negative breast cancer: New discoveries and practical insights for drug development

Kharazmi A

For instance, mice deficient in both GPX1 and GPX2 genes, spontaneously developed ileocolitis at a young age