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Recommended B12 Dosing and Timing During GLP-1 Treatment For patients on semaglutide, typical B12 supplementation recommendations include intramuscular injections of 1,000 mcg monthly, sublingual lozenges at 1,000-2,000 mcg daily, or oral supplements at 2,000 mcg or higher daily

Keeping logs of any symptoms, their timing, and their resolution

However, if it improves your adherence and tolerability, the theoretical pharmacokinetic disadvantage may not matter practically

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The magnitude varies based on lifestyle factors and individual biology

[DOI] [PubMed] [Google Scholar] 268.Han Y.-Y., Forno E., Rosser F., Celedn J.C