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Impaired clearance might also derive from disrupted peripheral A transport, as suggested by the sleep deprivation-induced downregulation of low-density lipoprotein receptor-related protein-1 (LRP-1), which promotes A efflux from the brain to the peripheral circulation across the BBB, and elevations of receptor of advanced glycation end products (RAGE), which promotes on the contrary the influx of peripheral A into the brain, thus preventing A clearance 149