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Indeed, it has been demonstrated a role of IGF-I signaling for maintaining glomerular integrity, restoring podocyte abnormalities, inhibiting podocyte apoptosis, and alterations in the glomerular basement membrane and the adjacent endothelial cell layer [140,363]

doi: 10.1002/smll.201700640 133 MoZQiuMZhaoKHuHXuQCaoJet al

doi: 10.1080/0886022X.2025.2453627

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Clustering provides strong support for the involvement of infectious agents, as with some cases of MS that appeared (100) in the Faroe Islands during World War II upon the arrival of foreign army corps, and was eventually shown to be due to EBV (101)