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Addition of extra heme increases the intensity of the A 410 signal indicating greater heme occupancy

Based on these reported findings, we offer a model where reduced GCLC expression under relative glucose abundance potentially underlies PDAC sensitivity to chemotherapy ( Fig

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3 Discussion Pharmacokinetic evaluations are necessary and vital for the development of new drugs

Journal of the American Chemical Society, 129, 45754583

Furthermore, oxidative stress can overwhelm the protein quality control systems, including the ubiquitinproteasome system and autophagy, impairing their ability to effectively degrade misfolded or damaged proteins [185, 186]