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Use bacteriostatic (not plain sterile) water for a multi-dose vial so the preservative supports the multi-draw window, and reconstitute gently down the vial wall rather than blasting the powder

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DNA is normally tightly packed in structures called nucleosomes, which involve the wrapping of DNA strands around proteins called histones - the tighter the DNA is packed, the more difficult it is for genes to be expressed

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The FDR of identified peptide-spectrum matches (PSMs) is calculated based on a consistent target-decoy approach, where random decoy peptides and spectra are generated by randomly permuting the peptide sequences and the fragment ions, respectively

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and van der Spoel D

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