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sublingual/injection routes can bypass this

The effects of thiamin and its phosphate esters on dopamine release in the rat striatum

This could affect energy balance, cholesterol levels, or insulin sensitivity

Methylmalonic acid (MMA) is a blood test that seems to be a better measure of vitamin B12 deficiency than serum vitamin B12 level

Not all B12 that you eat or take in supplements is absorbed and research indicates that to achieve a sufficient daily dose of B12, you should take at least five to 50 micrograms daily or 1,000 to 2,000 micrograms weekly (Del Bo et al., 2019

Proper mixing supports consistent treatment results for patients
