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Toxicology studies have shown no lethal dose (LD1) could be achieved in animal models, suggesting a wide therapeutic window
10.1038/6310 Nat
Lachowicz JI, Alexander J, Aaseth JO (2024) Cyanide and cyanogenic compoundstoxicity, molecular targets, and therapeutic agents
The drying process of blueberry pulp containing PCs at various temperatures (175 C, 200 C, and 225 C) leads to continuous degradation of the compound
69 This finding however has not yet been verified for mild TBI and warrants a double blind clinical trial
Within tumor cells, itaconate exerts anti-tumor effects predominantly as a result of the inhibition of the pentose phosphate pathway (PPP) enzyme glucose-6-phosphate dehydrogenase, G6PDH (encoded by the G6PD gene)
