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Deamidation breaks the backbone Asparagine and glutamine residues in the tirzepatide sequence are vulnerable to deamidation, a chemical reaction where the amide group converts to a carboxylic acid

doi: 10.1038/309163a0

This metabolic improvement occurs through AMPK pathway activation and increased NAD+-dependent SIRT1 activity, both of which enhance insulin receptor signaling and glucose metabolism

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