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JIMD Rep2019;49:70-9

Theyre also a good option for patients who have difficulty absorbing nutrients due to digestive issues, as they bypass the gastrointestinal tract entirely

The altered gene expression increases inflammation, potentially resulting in acne development

In addition, the concentration of 5MTHF in the CSF is lower than normal in patients with idiopathic cerebral folate deficiency, and some patients also have reduced concentrations of CSF 5-hydroxyindoleacetic acid and biopterin

In addition to the IF mechanism, passive diffusion normally accounts for 1-3% of B12 absorbed when obtained through normal food sources (3)

Deficiency may lead to brittle nails, hair loss, or dry, damaged skin