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Description
Many nutrients have their action INSIDE the cell, which means that testing serum and blood levels just give us an indication of what may be available but that is assuming everything else is working properly: cellular activity, enzyme activity, receptor activity, etc

As a case in point, Li and co-workers loaded dihydroartemisinin (DHA) into iron-based MOFs to design a peroxidase-like nanoreactor (termed DHA@MIL-101 NR) for synergistic CDT-ferroptotic therapy (Figure 5C) (Yang et al., 2022a)
While preliminary studies and observational signals suggest potential thyroidal effects, no RCTs have evaluated progression of Hashimoto thyroiditis or Graves disease under GLP-1RA therapy [32,58]

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These systems represent important investments to the organization and therefore need to be thoroughly researched and evaluated prior to selection

Hepatology 57 , 14161425 (2013)
