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Collectively, these findings suggest that modulating key factors within the HIF-1 signaling pathway, both upstream and downstream, can effectively optimize effector cell metabolism, diminish the proliferation and overactivation of abnormal, self-reactive cells, and subsequently ameliorate tissue inflammation in SLE patients, particularly those with LN

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Overexpression of Fas and FasL is associated with infectious complications and severity of experimental severe acute pancreatitis by promoting apoptosis of lymphocytes

Disturbances in these rhythms are implicated in retinal diseases, including AMD and DR (Liu WJ