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Numerous metabolic abnormalities found in MetS result in endothelial cell dysfunction by affecting NO synthesis or degradation
It is present in virtually every cell, with the highest concentrations in the liver, immune cells, and the lens of the eye
N., Mody, L
Immunity (2013) 39:697710
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Li, M., Li, C., Allen, A., Stanley, C
Research has found that under the influence of CORT, the expression of NLRP3 and caspase-1 in macrophages increases (caspase-1 promotes IL-1 maturation), leading to an increase in the circulating pro-inflammatory cytokine IL-1 (232)
