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doi: 10.1038/s41388-021-02155-z 45 AlbersMJBokRChenAPCunninghamCHZierhutMLZhangVYet al

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doi: 10.5798/diclemedj.0921.2012.04.0200

26 Recent literature has characterized GSH and other related metabolic enzymes as vital in protecting cells from ROS 27 through oxidation and reduction (redox) mechanisms

Research in Drosophila melanogaster demonstrated geroprotective effects at concentrations 16,000-80,000,000 times lower than those required for melatonin, suggesting Epithalon functions through highly efficient regulatory mechanisms rather than stoichiometric antioxidant consumption

Figure 4 To enhance the delivery of NPs to inflammation sites in CL, exploring alternative administration routes and tailoring NPs properties to evade rapid clearance by liver, spleen, and bone marrow macrophages is crucial