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Remarkably, the role of SIRT1 in maintaining viability is markedly blunted in NQO1-depleted cells

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All other chemicals and reagents were of analytical grade, and the water was glass-distilled

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Furthermore, succinate delivered via tumor-derived microvesicles triggers succinylation of isocitrate dehydrogenase 2 (IDH2) and histone H3K122, thereby enhancing lactate dehydrogenase A (LDHA) expression and forming a positive feedback loop that promotes glycolysis (134)