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When encountering microbial ligands, these receptors initiate cascades of signaling events leading to the activation of NF-B and other pro-inflammatory pathways

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The underlying mechanisms are multifactorial and not fully understood, but increasing evidence highlights the gutbrain axis and the intestinal microbiome as critical contributors to disease onset and progression ( 3.5.2 Microbiome alterations and the gutbrain axis in CFS/ME Multiple studies have established that individuals with CFS/ME exhibit significant alterations in their gut microbiome composition compared to healthy controls