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Although natural compounds such as resveratrol, quercetin, and curcumin target multiple pathways and show efficacy in preclinical MASLD models, their broad activity spectrum may result in off-target interactions

Glutathione reverses endothelial dysfunction and improves nitric oxide bioavailability

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For example, m6A modification could modulate RNA life via diverse mechanisms, but how these selective effects are determined in different cellular contexts remains unclear

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& Wittbrodt, J