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Even for bones, cartilage and joints, AOD-9604 may have potential applications

The Neelakantan 2018 paper showed strong oral absorption in cell uptake (Caco-2) assays, which is why most research community use is by mouth instead of by injection

The solvent Another possible cause of painful B12 injections is the solvent used to dissolve the B12 in the vial

Available from: Ng FM, Sun J, Sharma L, Libinaka R, Jiang WJ, Gianello R

The safety data for each compound individually is reassuring, but combination safety requires its own evaluation because pharmacological interactions can produce unexpected results even when each agent is well-characterized on its own

Weisel K