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The results shown by the present study strongly suggest that NAC administration inhibited ethanol-induced oxidative stress (GSSG/GSH ratio) activating the Nrf2-ARE system, which is in line with a report that an analog of NAC, NACA, attenuated the oxidative stress induced by a traumatic brain injury in rats via the same antioxidant system (Zhou et al., Whether an activation of xCT transporter function due to an increased substrate availability and/or an increased xCT expression plays a role in the NAC-induced reduction of hippocampal GSSG/GSH ratio, the administration of the xCT inhibitor SZ was expected to reduce or block such an effect of NAC

doi: 10.3390/ijms232314772

This means a greater proportion of glutathione is utilized, maximizing its antioxidant benefits

We use FDA-compliant allergen labeling, which identifies eight major food allergens: milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, and soybeans

Mass spectrometry analyses identified multiple proteins altered where pre-treatment with Molidustat reduced the affinity to the IOX4 beads (Supplementary Table S2)