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We have had many discussions about other patients over the years, and this was an opportunity to impact my patients care and to advance the field of precision therapeutics more broadly. Encouraged by these results, the researchers are now working with WashU Medicine chemists to develop a toolkit of targeted agents for treating rare diseases caused by the dysfunction of potassium ion channels

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To elucidate the role of GST and SULT against AITC, the protein (GST and SULT) and ligand (AITC) interactions were studied in the current investigation and it was found that leucine and aspartic acid are the key amino acids in mediating GST-AITC and SULT-AITC interaction, respectively

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Subsequently, the researchers demonstrated in laboratory experiments a suppression of mycobacterium abscessus infection of monocyte-derived macrophages by up to 65% (115)
