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J Neurosci 35:1599616011 Agarwal A, Wu PH, Hughes EG, Fukaya M, Tischfield MA, Langseth AJ, Wirtz D, Bergles DE (2017) Transient opening of the mitochondrial permeability transition pore induces microdomain calcium transients in astrocyte processes

This expression induces neurodegeneration in a time-dependent manner and is modulated by factors, which promote proper proteostasis

Mutations and damage to mitochondrial DNA can affect the function of oxidative phosphorylation complexes, leading to increased ROS generation