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If used in such cases, it requires close monitoring and shared decision-making with healthcare professionals

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Null mutations in Mc4r cause pronounced, dominantly inherited, monogenic obesity in rodents and humans, and are associated with increased food intake, decreased energy expenditure, and increased lean body and fat mass [56,57]

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According to the UK SmPC, the inactive ingredients (excipients) in Mounjaro include sodium chloride, sodium phosphate dibasic heptahydrate, sodium hydroxide and hydrochloric acid (for pH adjustment), and water for injections