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Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile

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Khan A, Khan MI, Iqbal Z, et al

Regarding the toxicity of the therapeutic agents and methodologies on the liver, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were assayed

Blood GSH increased (Cohens d = 1.01) and 8-OHdG decreased (Cohens d = 1.07) significantly within three months ( p 0.05) (Figure 2)

The fact that the excitatory effect of -Glu-Glu on synaptic transmission was blocked by TTX indicates that it most likely resulted from an indirect mechanism involving first the partial effect on NMDAr leading and second the endogenous synaptic release of glutamate and glycine, in turn activating both AMPAr and NMDAr ( The changes in -Glu-Glu in the extracellular medium may thus reflect the production of GSH by astroglial cells