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This review further elucidates the complex and context-dependent role of nuclear factor erythroid 2-related factor 2 (Nrf2)
Macrophages can be categorized into three main types: the unactivated M0 type, the classically activated pro-inflammatory M1 type, and the alternatively activated anti-inflammatory M2 type (Zhao and Zhao, 2019
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This cascade then activates endothelial nitric oxide synthase through Ser1177 phosphorylation, generating the nitric oxide that drives vessel formation
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PRECLINICAL STUDIES OF SULFORAPHANE As summarized in Table 1, sulforaphane (and in a few cases broccoli sprout extract) have been evaluated as inhibitors of experimental carcinogenesis utilizing chemical carcinogens, genetic models and tumor xenografts
