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Thus, targeting glutamine metabolism not only inhibits glutamine-dependent pathways, but also leads to a marked decrease in p-STAT1 and p-STAT3dependent IDO expression resulting in a robust reversal of the kynurenine/tryptophan ratio

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Maintaining the biconcave shape of RBCs is essential, enabling them to circulate through capillaries while preventing hemolysis that could release Hb into the intravascular space, causing harmful effects [11]

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doi: 10.1016/j.bbalip.2017.03.012 286 TuckerS.MllerC.TegerstedtK.LordA.LaudonH.SjdahlJ.et al