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In an animal model of fetal alcohol disorders, T4 expression was upregulated in protective microglial cells of the stress-sensitive hippocampus, and giving exogenous T4 reduced activation of pro-inflammatory networks and their secretion of cytokines including TNF, IL-1, and iNOS

(2003) 53:S2638

[DOI] [PubMed] [Google Scholar] 14.Geier DA, Kern JK, Garver CR, Adams JB, Audhya T, Geier MR

A bispecific antibody to factors IXa and X restores factor VIII hemostatic activity in a hemophilia A model

2) Why physicians prescribe compounded drugs Patient-specific formulations: Alternative strengths, routes (e.g., rectal suppositories for GI indications), or dosage forms

Additionally, epipolythiodioxopiperazine derivatives of gliotoxin with the dithiol group showed weaker cytotoxicity compared with gliotoxin, and gliotoxin derivates of the methylthio group showed much weaker cytotoxicity than that of dithiol gliotoxin