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Its primary function at inception was clinical: give pharmacists and prescribers a reference for which generic products the FDA considered therapeutically equivalent to brand-name drugs, enabling pharmacy-level substitution
Important factors potentiating AKI in these patients are extracellular volume depletion due to vomiting, diarrhoea, urinary tract obstruction, fluid and electrolyte disturbances, exposure to contrast media, nephrotoxic antibiotics, non-steroidal anti-inflammatory drugs and nephrotoxicity of some of the anti-cancer treatments [24]

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