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Description
Many small-molecule compounds with potent ferroptosis-inducing activity suffer from poor in vivo stability, rapid metabolism, low tumor tissue accumulation efficiency, and systemic toxicity, which limit their clinical application (125, 184)

Further, KD should not be used in patients with chronic kidney disease, liver failure, hypertriglyceridemia-induced acute pancreatitis, heart failure, especially NYHA Class IV, eating disorders, respiratory failure, as well as in the elderly, and during pregnancy and lactation (52, 62, 63, 67, 68)

[DOI] [PubMed] [Google Scholar] 3.Kaugars GE, Heise AP, Riley WT, Abbey LM, Svirsky JA
The block at MCAD prevents oxidation of medium chain CoA to short chain CoA, thereby markedly reducing the production of ketones
meaning that they are active primarily at night

However, results vary by individual, and stem cell therapy for ED is still classified as an emerging treatment