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3.2.2.4 Nitric oxide (NO) NO, which is mainly produced by different isoforms of nitric oxide synthase (NOS) with arginine as a substrate, is closely associated with vascular endothelial cells and nerve cells, and can cause muscle diastole by increasing cGMP and decreasing Ca 2+ concentrations in smooth muscles through a series of processes

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[DOI] [PMC free article] [PubMed] [Google Scholar] 81.Uchida K

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