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Moreover, when studying the role of cortical astrocytes in a mouse model of cerebral hemorrhage [intracerebral hemorrhage (ICH)], researchers found that MLT activates astrocytes through PKC/Nrf2/HO-1 signaling pathway to acquire resistance to the toxicity of hemin and resist from oxidative stress (Ishii et al., 2019)
however, separate analyses according to RhD phenotype revealed that this effect was significant only in RhD-negative individuals (odds ratio = 2.53, 95% CI: 1.125.70, p = 0.026)
Methods 19 , 341352 (2022)
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They also fight free radicals that lead to early aging
