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FIGURE 1 Animals were fed either Research Diet D12492 (HFD) or D12450j (LFD) (Research Diets, New Brunswick NJ) and treated with daily intraperitoneal injections of 8 mg/kg rapamycin (LC Laboratories, Woburn MA) (cohort 1 and 2), daily intraperitoneal injections of 2.5 mg/kg, 5 mg/kg, 10 mg/kg, or 25 mg/kg adefovir dipivoxil (cohorts 2 and 3) (Carbosynth, UK), or with adefovir dipivoxil mixed in the chow for 6 weeks at 21 mg/kg, 42 mg/kg, 84 mg/kg, or 210 mg/kg w/w (cohorts 2 and 3)