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Further evidence supporting the potential in situ deleterious effects of APAP in brain comes from studies showing that APAP increases neuronal CYP2E1 enzymatic activity and protein levels, leading to neuronal cell death through mitochondrial-mediated mechanisms that involve cytochrome c release and caspase 3 activation (130)

Penn et al

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EU IGFD Registry Study Group

Schmidt U, Conrad R (1993) Hydrogen, carbon monoxide, and methane dynamics in lake Constance limnol
