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The development of alcohol dependence is a complex and dynamic process that involves profound perturbations in neuroendocrine systems (i.e., HPA axis activity) as well as neuroadaptations in a host of neurochemical systems, including classic neurotransmitter systems (e.g., glutamate, GABA, monoamines), neuropeptides (e.g., CRF, NPY, endogenous opioids), and numerous ion channels (e.g., VGCCs, SK channels, BK channels)