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After the above reaction was completed, the above solution was allowed to cool to room temperature

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Strikingly however, the majority of sporadic ALS patients (up to 97%) also contain the TDP-43 protein deposited in the neuronal inclusions, which suggests of its pivotal role in the ALS pathology

In preclinical research settings, NNMT modulation is investigated for its downstream influence on NAD + -related biochemical pathways and cellular energy regulation

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