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Proteomics Clin Appl

As functioning muscle tissue is one of the few sources of brain-derived neurotrophic factor, this leads to impaired memory and cognition [136]

J Clin Endocrinol Metab 98(3):10311039

Volume 16: 3263

TMAO promotes macrophage infiltration and activation within adipose tissue, driving a shift in macrophage phenotype toward the pro-inflammatory M1 state, contributing to adipose tissue dysfunction, a key hallmark of obesity-related metabolic dysfunction [30, 75]