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Additionally, MG treatment showed selectivity for mitochondrial respiration inhibition in malignant cells compared to normal cells [130]

10.1074/jbc.M305063200 10.1074/jbc.M305063200 [DOI] [PubMed] [Google Scholar] Stancill JS, Broniowska KA, Oleson BJ, Naatz A, Corbett JA (2019) Pancreatic -cells detoxify H2O2 through the peroxiredoxin/thioredoxin antioxidant system

CHAC2 itself is regulated both transcriptionally and post-translationally, with its degradation mediated by the ubiquitin-proteasome pathway ( In lung cancer, however, the CHAC2-mediated increase in ROS triggers the MAPK pathway

LpezOtn C., Blasco M

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Wang YL, Wang DH, Wei GY, Shao N (2012) Enhanced co-production of S-adenosylmethionine and glutathione by an ATP-oriented amino acid addition strategy