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Adaptive immunity is represented by B and T lymphocytes providing antigen-specific responses ( Epigenetic regulation of the immune system.Epigenetic modifications are functionally connected to the differentiation, activation, function, and exhaustion of immune cells ( Supplementary Figure 1 )

Yadav SS, Singh MK, Singh PK, Kumar V

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In pernicious anaemia, the immune system mistakenly attacks the gastric parietal cells that produce intrinsic factor, leading to B12 deficiency over time