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A recent systematic review and meta-analysis of 21 randomized, placebo-controlled trials examining the effect of B-vitamin supplementation found the supplementation decreased homocysteine concentrations and improved measures global cognitive function but had no effect on individual measures of executive function, information processing speed, or episodic memory (89)

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This distinction alone fundamentally changes the treatment calculus, because chronic conditions typically require chronic treatment, and obesity is a chronic condition

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L-NAME opposes healing and decreases bleeding time, whereas L-arginine promotes healing and prolongs bleeding time[3,51]), we conducted a parallel investigation of the effects of NOS blockade (L-NAME) and NOS substrate (L-arginine) administration, which is an important point that should be addressed[3]