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23 Psychological stress can activate the hypothalamic-pituitary-adrenal axis, promoting the release of inflammatory factors such as interleukin-1 and tumor necrosis factor, thereby intensifying the facial erythema symptoms in patients

Yet, under regulation of the ISR pathway an ATF4-mediated upregulation of NRF2 via CHAC1 activity was shown as well ( 2.3.1 The dual role of CHAC1 in cancer CHAC1s function in cancer is complex and highly context-dependent

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In contrast to the canonical pathway, the non-canonical NF-B activation does not involve IB degradation but is dependent on the p100 (NF-B2) precursor protein