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For example, G6PD Betica, 66 a Spanish variant and G6PD Matera, 67 an Italian variant, have demonstrated base substitutions at nucleotides 202 and 376, identical to the common G6PD A variant

This imbalance can result in heavy periods, breast tenderness, bloating, mood swings, and PMS

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These stressors can damage cellular components, trigger ROS production, and induce ferroptosis by overwhelming antioxidant defenses mediated by GPX4, as well as disrupting the cysteine-glutathione axis via System Xc- (145)