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NAD+ (nicotinamide adenine dinucleotide) plays a critical role in energy production, brain function, metabolism, and healthy aging

& Lang, R
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NOX1 (NADPH Oxidase 1, Santa Cruz Biotechnologies, Dallas, TX), NOX2 (gp91 phox, Upstate Biotech/Thermo Fisher Scientific), and HO-1 (Enzo Life Sciences, Farmingdale, NY)

Thus increased stretch and its subsequent stimulation of vascular oxidant stress may contribute to the cellular dysfunction encountered in the wall of varicose veins (Figure 3) [62]

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