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In addition to intracellular effects, itaconate is secreted from activated macrophages, particularly within the tumor microenvironment, where it exerts numerous additional effects
R., Podell, E
Figure 4A shows the representative micrographs with notable reduced demyelination in UA-treated animals
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Control mice were homozygous for the loxP-flanked Ghr allele, whereas their littermates carrying the Cre alleles were considered the conditional knockout mice
