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Punch biopsy: reveals epidermal hyperkeratosis, hypergranulosis, plugged hair follicles, and mild superficial perivascular lymphocytic inflammation

Advantages of PRP therapy: Stimulates collagen production to improve skin quality and elasticity

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They are typically prescribed when oral supplements are ineffective or when rapid improvement of symptoms is required

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RGD-GHK significantly promoted the mRNA level of loricrin (LOR) and filaggrin (FLG), which were associated with a marked reduction in the damaged skin barrier