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This increased availability of glutathione may contribute to a more pronounced skin-brightening effect

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It has been observed that repeated doses of DCA resulted in loss of GSTZ1-1 protein and activity, probably due to post-translationally modifications of the enzyme 85

Understandably, the effect of such locally applied topicals remains limited to the application site alone without any notable systemic skin lightening effect

PMID: 33942088

And thats the philosophy behind Glutafine