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Once you have it, you have it, is how I understand it because its intracellular

[DOI] [PMC free article] [PubMed] [Google Scholar] 114.Michelet L., Zaffagnini M., Massot V., Keryer E., Vanacker H., Miginiac-Maslow M., Issakidis-Bourguet E., Lemaire S.D

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As the central enzyme of the endogenous lipogenesis pathway, fatty acid synthase (FAS) is directly involved in regulating lipid deposition, making it a critical marker for assessing dietary effects (Schroeder et al., 2021)

MacKeigan JP, Murphy LO, Blenis J (2005) Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance

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