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Under oxidative stress conditions, NRF2 separates from Keap1 and activates the expression of downstream target genes containing antioxidant response elements (ARE), such as iron heavy chain protein (FTH1) and iron light chain protein (FTL), promoting GSH synthesis and regenerating NADPH to exceed ROS production (83)
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The effect is markedly stronger for GHRP-6, which in animal models significantly stimulates food intake
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doi: 10.3390/jox13020017 95 HeoJWYangJDYumSKLeeHJKimSHKimDKet al
Chemistry 19:1155811563 Bonifacic M, Asmus KD (1976) Free radical oxidation of organic disulfides
