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Zeng D, Liang YK, Xiao YS, Wei XL, Lin HY, et al

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CRISPR/Cas9-mediated vimentin knockout (VIM KO) in THP-1 macrophages resulted in an inability to form DLPs-equipped macrophages, characterized instead by the continuous initiation of bleb-like growth cones (Fig

found patterning signals like Shh expression were downregulated over time while expression of synthetic genes like TGF- and insulin growth factor (IGF) were upregulated in the same developmental window, providing insights into gene families required for patterning, ECM synthesis, and maintenance of the NP